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NFL week 15 odds & picks

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 · 1d
Opening NFL Week 15 Odds and Betting Lines: Buffalo -1.5 at New England
Get the opening NFL Week 15 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Dec. 11, 2025.

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SportsLine · 7h
NFL odds, lines, spreads: 2025 Week 15 picks, predictions from proven model: 5-way parlay pays 25-1
 · 8h
NFL Week 15 early predictions: Best bets, picks to target before lines move
9h

NFL Week 15 early odds: Patriots underdogs at home vs. Bills, Seahawks favored big vs. Daniel Jones-less Colts

Meanwhile, both the Los Angeles Rams and Denver Broncos leapt to the No. 1 seed in their respective conference thanks to the ...
8h

NFL Week 15 odds, spreads: Bills-Patriots, Lions-Rams lead slate

The marquee games for Week 15 reflect this shifting reality. The Buffalo Bills (-1.5) are narrowly favored at New England.
9h

NFL Power Rankings Based on Super Bowl Odds Ahead of Week 15 (Packers, Bills, Jags Rise)

There's a new No. 1 seed in the AFC and NFC through 14 weeks of the 2025 season, as the Denver Broncos (11-2) have taken the ...

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